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Editor’s note
It is well established that secure healing between the rotator cuff tendon and bone after repair is often unpredictable and challenging to achieve. The normal tendon–bone insertion site is a highly sp...
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Leesa M. Galatz,
Scott A. Rodeo
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147-148
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| Special Issue on Rotator Cuff Biology and Healing |
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Measurement of in vivo tendon function
Chronic tendon pathologies (eg, rotator cuff tears, Achilles tendon ruptures) are common, painful, debilitating, and a significant source of medical expense. Treatment strategies for managing tendon p...
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Michael J. Bey,
Kathleen A. Derwin
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149-157
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Basic mechanisms of tendon fatigue damage
Pathologic processes intrinsic and extrinsic to the tendons have been proposed as the underlying cause of rotator cuff disease, but the precise etiology is not known. Tear formation is, in part, attri...
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Andrew Neviaser,
Nelly Andarawis-Puri,
Evan Flatow
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158-163
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Muscle degeneration in rotator cuff tears
Rotator cuff tears are among the most common injuries seen by orthopedic surgeons. Although small- and medium-sized tears do well after arthroscopic and open repair, large and massive tears have been ...
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Dominique Laron,
Sanjum P. Samagh,
Xuhui Liu,
Hubert T. Kim,
Brian T. Feeley
et al.
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164-174
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Mechanisms of fatty degeneration in massive rotator cuff tears
Fatty degeneration of chronically injured muscle is a commonly recognized consequence of massive rotator cuff tears. Current surgical treatments are unable to alter or reverse the progression of fatty...
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Jason R. Kang,
Ranjan Gupta
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175-180
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Biologic approaches to enhance rotator cuff healing after injury
Background: Despite the advances in surgical procedures to repair the rotator cuff, there is a high incidence of failure. Biologic approaches, such as growth factor delivery and stem cell and gene the...
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Christian Isaac,
Burhan Gharaibeh,
Michelle Witt,
Vonda J. Wright,
Johnny Huard
et al.
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181-190
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Lessons we can learn from gene expression patterns in rotator cuff tears and tendinopathies
Persistently high failure rates that are reported after rotator cuff repairs have encouraged greater understanding of the pathophysiology that underlies rotator cuff tears. Biologic changes that contr...
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Salma Chaudhury,
Andrew J. Carr
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191-199
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Metalloproteases and rotator cuff disease
The molecular changes occurring in rotator cuff tears are still unknown, but much attention has been paid to better understand the role of matrix metalloproteinases (MMP) in the development of tendino...
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Angelo Del Buono,
Francesco Oliva,
Umile Giuseppe Longo,
Scott A. Rodeo,
John Orchard,
Vincenzo Denaro,
Nicola Maffulli
et al.
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200-208
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Potential of collagen cross-linking therapies to mediate tendon mechanical properties
Collagen cross-links are fundamental to the mechanical integrity of tendon, with orderly and progressive enzymatic cross-linking being central to healthy development and injury repair. However, the no...
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Gion Fessel,
Christian Gerber,
Jess G. Snedeker
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209-217
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Cytokines in rotator cuff degeneration and repair
The pathogenesis of rotator cuff degeneration remains poorly defined, and the incidence of degenerative tears is increasing in the aging population. Rates of recurrent tear and incomplete tendon-to-bo...
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Asheesh Bedi,
Travis Maak,
Christopher Walsh,
Scott A. Rodeo,
Dan Grande,
David M. Dines,
Joshua S. Dines
et al.
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218-227
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The role of mechanobiology in tendon healing
Mechanical cues affect tendon healing, homeostasis, and development in a variety of settings. Alterations in the mechanical environment are known to result in changes in the expression of extracellula...
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Megan L. Killian,
Leonardo Cavinatto,
Leesa M. Galatz,
Stavros Thomopoulos
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228-237
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The role of nitric oxide in tendon healing
Nitric oxide (NO) is a small free radical that is generated by a family of enzymes called the nitric oxide synthases (NOS). There are 3 isoforms of NOS: endothelial NOS (eNOS), brain or neuronal NOS (...
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Ali R. Bokhari,
George A.C. Murrell
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238-244
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Fiber-aligned polymer scaffolds for rotator cuff repair in a rat model
Background: Repair techniques of rotator cuff tendon tears have improved in recent years; nonetheless, the failure rate remains high. Despite the availability of various graft materials for repair aug...
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David P. Beason,
Brianne K. Connizzo,
LeAnn M. Dourte,
Robert L. Mauck,
Louis J. Soslowsky,
David R. Steinberg,
Joseph Bernstein
et al.
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245-250
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Scaffold devices for rotator cuff repair
Rotator cuff tears affect 40% or more of those aged older than 60 years, and repair failure rates of 20% to 70% remain a significant clinical challenge. Hence, there is a need for repair strategies th...
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Eric T. Ricchetti,
Amit Aurora,
Joseph P. Iannotti,
Kathleen A. Derwin
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251-265
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Biomimetic scaffold design for functional and integrative tendon repair
Rotator cuff tears represent the most common shoulder injuries in the United States. The debilitating effect of this degenerative condition coupled with the high incidence of failure associated with e...
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Xinzhi Zhang,
Danielle Bogdanowicz,
Cevat Erisken,
Nancy M. Lee,
Helen H. Lu
et al.
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266-277
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Cell- and gene-based approaches to tendon regeneration
Repair of rotator cuff tears in experimental models has been significantly improved by the use of enhanced biologic approaches, including platelet-rich plasma, bone marrow aspirate, growth factor supp...
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Alan J. Nixon,
Ashlee E. Watts,
Lauren V. Schnabel
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278-294
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| Case Reports |
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High-resolution 3-Tesla magnetic resonance neurography of musculocutaneous neuropathy
02 September 2011
The musculocutaneous nerve originates from the lateral cord of the brachial plexus, with contributions from the C5, C6, and C7 nerve roots. Once the musculocutaneous nerve leaves the lateral cord, it ...
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Avneesh Chhabra,
Pearlene P. Lee,
Cary Bizzell,
Neda Faridian-Aragh,
Shar Hashemi,
Alan J. Belzberg,
John A. Carrino
et al.
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e1-e6
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Extremely rare synovial chondrosarcoma arising from the elbow joint: case report and review of the literature
10 October 2011
Primary synovial chondromatosis is benign disease of the mucosal membrane in the joint. This disease often affects the knee joint but rarely the elbow joint. Chondrosarcoma, however, is a common malig...
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Keiichi Muramatsu,
Tomoyuki Miyoshi,
Atsushi Moriya,
Hiroshi Onaka,
Mitsunori Shigetomi,
Daisuke Nakashima,
Toshihiko Taguchi
et al.
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e7-e11
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Triceps avulsion, radial head fracture, and medial collateral ligament rupture about the elbow: a report of 4 cases
17 October 2011
Triceps tendon rupture is a rare but well-reported entity. Three of these reports have documented the occurrence of a triceps avulsion with a radial head fracture. There have also been reports of tric...
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Michele Y. Yoon,
Mark J. Koris,
Jose A. Ortiz,
Rick F. Papandrea
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e12-e17
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Sequential ipsilateral glenohumeral arthrodesis and scapulothoracic fusion: a case report
10 October 2011
Glenohumeral arthrodesis is a well-established surgical procedure with a variety of indications, which include brachial plexus palsies and other paralytic disorders. Disorders requiring scapulothoraci...
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Syed A. Faisal,
Peter T. Campbell,
Allan P. Skirving
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e18-e20
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| Frontmatter |
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Contents
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A1-A3
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Sponsoring Societies
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A4
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Editorial Board
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A5
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